Update (5:25 p.m.): Police say both drivers were taken to local hospital.
The female driver of the car was later airlifted to a Toronto hospital with "serious" injuries, according to Barrie police communications co-ordinator Peter Leon.
The two drivers were the only occupants in their vehicles, he added.
The on-scene investigation continues.
More information is expected to be released Wednesday morning.
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ORIGINAL STORY
Members of the Barrie police traffic unit are on the scene of a "serious" crash on Ellis Drive in the city's south end this afternoon.
Around 4 p.m. Tuesday, police said the collision involves a car and a transport truck.
Ellis Drive is closed at Welham Road for the investigation.
Police say Ellis Drive will be closed until further notice to allow the investigation to safely take place.
BarrieToday will have more information as it becomes available.